Nonthrombocytopenic purpura

Nonthrombocytopenic purpura
Classification and external resources
ICD-9	287.2

Nonthrombocytopenic purpura is a type of purpura (red or purple skin discoloration) not associated with thrombocytopenia.^[1]

Examples/causes include:

References

^ ^a ^b "MedlinePlus Medical Encyclopedia: Purpura". http://www.nlm.nih.gov/medlineplus/ency/article/003232.htm. Retrieved 2009-01-06.
^ "Evaluating the Child with Purpura - August, 2001 - American Family Physician". http://www.aafp.org/afp/20010801/419.html. Retrieved 2009-01-06.
^ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. pp. 650. ISBN 0-7216-0187-1.

↑

Poly- cythemia	Polycythemia vera

↓

Hereditary	enzymopathy: G6PD · glycolysis (PK, TI, HK) hemoglobinopathy: Thalassemia (alpha, beta, delta) · Sickle-cell disease/trait · HPFH membrane: Hereditary spherocytosis (Minkowski-Chauffard syndrome) · Hereditary elliptocytosis (Southeast Asian ovalocytosis) · Hereditary stomatocytosis

Acquired	Autoimmune (WAHA, CAD, PCH) membrane (PNH) MAHA · TM (HUS) Drug-induced autoimmune · Drug-induced nonautoimmune Hemolytic disease of the newborn

Other

↑

Hyper- coagulability	primary: Antithrombin III deficiency · Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden · Hyperprothrombinemia acquired:Thrombocytosis (essential) · DIC (Congenital afibrinogenemia, Purpura fulminans) · autoimmune (Antiphospholipid)

↓

Thrombocytopenia	Thrombocytopenic purpura: ITP (Evans syndrome) · TM (TTP) Heparin-induced thrombocytopenia · May-Hegglin anomaly

Platelet function	adhesion (Bernard–Soulier syndrome) · aggregation (Glanzmann's thrombasthenia) · platelet storage pool deficiency (Hermansky–Pudlak syndrome, Gray platelet syndrome)

Clotting factor	Hemophilia (A/VIII, B/IX, C/XI) • von Willebrand disease • Hypoprothrombinemia/II · XIII · Dysfibrinogenemia

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

Decreases

Thrombus/thrombosis	Renal vein thrombosis

Ischemia	Brain ischemia · Ischaemic heart disease · Ischemic colitis/Mesenteric ischemia

Infarction	general: Anemic infarct · Hemorrhagic infarct regional: Myocardial infarction · Cerebral infarction · Splenic infarction · Limb infarction

Increases

Hemorrhage	general Bruise/Hematoma: Petechia · Purpura · Ecchymosis regional: head (Epistaxis, Hemoptysis, Intracranial hemorrhage, Hyphema, Subconjunctival hemorrhage) · torso (Hemothorax, Hemopericardium, Pulmonary hematoma) · abdomen (Gastrointestinal bleeding, Haemobilia, Hemoperitoneum, Hematocele, Hematosalpinx ) · joint (Hemarthrosis)

Edema	general: Anasarca · Angioedema/Lymphedema · Exudate/Transudate regional: Cerebral edema · Pulmonary edema · Hydrothorax · Ascites/hydroperitoneum · Hydrosalpinx

Other	Hyperemia